The show, which began as a story about a group of sci-fi-loving intellectuals who form a pseudo family, saw some dips in its ratings last year but largely remained a stalwart for CBS.
The decision to bring the show to an end likely came despite efforts from the network to secure another season.
Earlier this month, CBS Entertainment president Kelly Kahl said the network did not believe Season 12 would be it’s last, saying they were “in preliminary discussions to renew the show.”
The series stars Parsons, Johnny Galecki, Simon Helberg, Kunal Nayyar, and Kaley Cuoco, as well as Bialik and Melissa Rauch, who joined the fold in later seasons.
At its conclusion, the show will have aired 279 episodes.
The final season debuts September 24.